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This book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis.
This comprehensive reference text is based on the master’s courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.
- Sales Rank: #3490013 in Books
- Published on: 2016-10-12
- Released on: 2016-10-12
- Original language: English
- Number of items: 1
- Dimensions: 9.25" h x .83" w x 6.10" l,
- Binding: Paperback
- 328 pages
Review
“Aiming not only at helping the medical oncology community, especially those who are in daily practice, but also the pharmacologists, physicians and scientists in the pharmaceutical industry, this textbook provides a very useful guide. … Each chapter is followed by selected and updated bibliographic references. This textbook is a very valuable didactic aid to the clinical oncologist and to those in the pharmaceutical industry who are interested in anticancer agents.” (Ferdy J. Lejeune, Melanoma Research, Vol. 26, 2016)
From the Back Cover
This book provides a simplified, yet comprehensive, overview of the signalling pathways operating between and inside cells, which will help younger oncologists find their way in the labyrinth of signalling pathways and in the multitude of signals and signal receptors, transducers and effectors that contribute to oncogenesis.
This comprehensive reference text is based on the master’s courses delivered by Prof. Jacques Robert to graduate students at the University of Bordeaux, France. It includes a large number of colour schemas and figures that have been improved year after year for educational purposes. Signalling pathways are described individually and in depth, but without ignoring the multiplicity of interconnections and crosstalk. The presentation of each pathway is followed by a brief description of the alterations found in cancers as well as of the targeted pharmacological approaches that can be used to prevent or overcome the consequences of these oncogenic alterations. The basic mechanisms of molecular biology at the DNA replication, RNA transcription and protein activity levels are presented in a series of didactic annexes, enabling readers to better understand the alterations in signalling pathways.
About the Author
Jacques Robert is a Professor of Biological Oncology at the University of Bordeaux, France and currently teaches cell biology, basic oncology and molecular pharmacology to medical and scientific students, with special courses on new developments in cancer targeted therapies. He is an oncobiologist at the department of Biopathology of Institut Bergonié, the Comprehensive cancer centre of Bordeaux, and is responsible for the routine and specialised clinical chemistry tests performed in patients. His research activities at INSERM U916 are focused on the molecular determinants of the activity of anticancer drugs, both at the levels of the patient’s genome (pharmacogenetics) and at the level of the tumour genome (pharmacogenomics). This activity is developed on both in vitro and in vivo models and at the level of clinical studies aiming at identifying the genetic factors involved in the efficiency and toxicity of classical and targeted anticancer drugs, especially in colorectal, head-and-neck and breast cancers.
Most helpful customer reviews
0 of 0 people found the following review helpful.
A Must Read for Beginners and Experts
By Dr. Terrence McGarty
The book by Robert, the Textbook of cancer signaling, is one of the best works on cell signaling available as an introduction. As the author indicates in the preface the intent is for oncologists to obtain a better perspective of the issues associated with the wealth of new therapeutics as well as some of the key issues behind their introduction. For the most part the work is a high level, but not simplistic, organization and presentation of the key signaling paths. The general approach is to detail one class of paths after another and describe in excellent detail the elements of those pathways and how they function. Then there is a brief exposition of how aberrations in the pathways lead to oncogenic effects and then a discussion on pharmacological possibilities. This is done chapter by chapter.
The author’s collection and organization is superb and it presents the reader with an organization that they can come back to time and time again. He covers kinases, including MAP and other elements, cytokines, TGF, G protein, Wnt, Notch, and Hedgehog. He also discusses integrins and a collection of adhesion molecules. There is a discussion of B and T cell issues including Toll Like receptors and lymphocytic receptors. He ends with excellent discussions on cell cycle control as well as apoptosis.
The Appendices are superb summaries of DNA control, gene expression and protein activity. Overall this is a book that should be on the desk of almost every oncologist and it is an excellent summary for those involved in pathway analysis and their implications.
The most important elements of the book are the author’s organization and integration. It is simple, straightforward and touches on all the current elements under consideration.
This is not a book for the specialist but it is worth reading by those deeply involved in that work to see haw one person who truly understands the depth and breadth sees it structured.
On the side of a critique, and this is hard given the superb effort displayed, issue such as epigenetic factors should have gotten some bit of discussion. Specifically the issue of methylation and miRNA silencing need to be integrated into the overall signaling fabric. However that would clearly have extended and expanded the work
Also the reader should not look at this as a reference book, it was not intended as such.
Finally my only one negative is the lack of an Index. That most likely is a publisher problem and not the author’s problem. The lack of an index is not that serious since the author has organized the book so well it is almost not necessary.
I would strongly recommend this book for anyone seeking to learn pathway issues in cancer and those who are deeply involved already. The logical wholeness of the work is worth understanding by all.
1 of 2 people found the following review helpful.
When will publishers get it thru their heads you need a bigger eBook contents sample?
By D. Covington
Ebook sample only includes the Table of conents. Insuffcient to decide if the book is usable to the lay person.
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